ea0015p320 | Steroids | SFEBES2008
Hardy Rowan
, Augustine Dona
, Kaur Kirren
, Slabbert Ana
, Raza Karim
, Buckley Chris
, Stewart Paul
, Rabbitt Elizabeth
, Cooper Mark
High dose glucocorticoids are effective in suppressing inflammatory synovitis but have adverse effects on other connective tissues. In inflammatory arthritis glucocorticoids suppress the capacity of synovial fibroblasts (SFs) to recruit leukocytes to the joint whereas poor skin healing is due to impaired dermal fibroblast (DF) function. It is unknown whether these clinical differences are due to similar or distinct effects of glucocorticoids on fibroblast function.<p class...